TY  - EJOU
AU  - Andrés, Clara de 
AU  - Rodríguez-Sáinz, M. Carmen 
AU  - Muñoz-Fernández, M. Angeles 
AU  - López-Lazareno, Nieves 
AU  - Rodríguez-Mahou, Margarita 
AU  - Vicente, Angeles 
AU  - Fernández-Cruz, Eduardo 
AU  - Sánchez-Ramón, Silvia 

TI  - Short-term sequential analysis of sex hormones and helper T cells type 1 (Th1) and helper T cells type 2 (Th2) cytokines during and after multiple sclerosis relapse
T2  - European Cytokine Network

PY  - 2004
VL  - 15
IS  - 3
SN  - 1952-4005

AB  - Multiple sclerosis (MS) is an immune-mediated disease with a clear sex-bias that may be attributed
to sex hormones, sex’ linked genes or both. Here we sought to determine the evolution pattern of cortisol and sex
hormones at MS relapse and 2-months later in 7 male patients with relapsing remitting MS, and whether there
was a correlation with a specific Th1 and Th2 cytokine pattern. Our findings indicate the activation of the
hypothalamic-pituitary-adrenal axis and the concomitant upregulation of pro- and anti-inflammatory cytokines
during relapse. The further increase of sex hormones, in particular estradiol in our male MS patients suggest their
possible implication in the physiopathology of the illness and a putative anti-inflammatory and neuroreparatory
effect.
KW  - cytokines; hypothalamo-pituitary-adrenal axis; multiple sclerosis

DO  -