@Article{,
AUTHOR = {Caroline Diveu, Anne-Hélène Lagrue Lak-Hal, Josy Froger, Elisa Ravon, Linda Grimaud, Fabien Barbier, Jacques Hermann, Hugues Gascan, Sylvie Chevalier},
TITLE = {Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling},
JOURNAL = {European Cytokine Network},
VOLUME = {15},
YEAR = {2004},
NUMBER = {4},
PAGES = {291--302},
URL = {http://www.techscience.com/ECN/v15n4/66359},
ISSN = {1952-4005},
ABSTRACT = {Gp130-like receptor (GPL) is a newly identified cytokine receptor. A recent study reported the
involvement of GPL, together with OSMR, in the formation of the receptor complex for IL-31, a novel immune
cytokine with a skin tropism. In the present work, we analyzed the signaling properties of IL-31 in glioblastoma
and melanoma tumor cells. We demonstrate that in response to IL-31, its receptor complex recruits Jak1, Jak2,
STAT1, -3, -5 signaling pathways, as well as the Pi3 kinase / AKT cascade. SHP-2 and Shc adapter molecules are
also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Different
responses were observed depending on the expression of short or long GPL receptor isoform within the studied
cell lines. We show that the short form of GPL receptor exerts a profound inhibitory effect on the signaling of
IL-31 and behaves as a dominant negative receptor.},
DOI = {}
}