@Article{,
AUTHOR = {J. Alonso Fernández, Lorena Tapia, M. Angélica Palomino, Carmen Larrañaga, Mónica Peña, Héctor Jaramillo},
TITLE = {Plasma interferon-γ, interleukin-10 and soluble markers of immune activation in infants with primary adenovirus (ADV) and respiratory syncytial virus (RSV) infection},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {1},
PAGES = {35--40},
URL = {http://www.techscience.com/ECN/v16n1/66234},
ISSN = {1952-4005},
ABSTRACT = {Adenovirus (ADV) and respiratory syncytial virus (RSV) are etiological agents of acute respiratory
tract infection in infants. Long-term prognosis of ADV infection includes severe lung damage, bronchiectasis and
hyperlucent lung, while RSV infection is associated with development of recurrent wheezing and subsequent
asthma. These differences may be related to differences in the primary immune responses elicited by these viruses.
In this paper, we investigated the type of cytokine responses and the magnitude of immune activation in ADV and
RSV infections in infants. We examined plasma concentrations of interferon-c (IFN-c), interleukin-10 (IL-10),
soluble interleukin-2 receptor (sCD25) and soluble tumor necrosis factor receptor II (sTNFR-II) in previously
healthy infants during the acute phase of primary ADV infection (n = 21) and RSV infection (n = 68), and in
uninfected controls (n = 44). In ADV-infected infants, IFN-γ plasma levels were significantly higher than those
observed in RSV cases and the control group (p < 0.05). RSV cases did not show any differences in IFN-γ plasma
levels compared to the other groups. sCD25 levels were significantly higher in ADV- and RSV-infected infants than
in controls (p < 0.0001), and higher in ADV than in RSV cases (p < 0.05). sTNFR-II levels were significantly higher
in RSV- and ADV-infected infants than in controls (p < 0.0001, p < 0.05, respectively), and higher in RSV than in
ADV infection (p < 0.05). No significant differences were observed in IL-10 plasma concentrations between the
three groups. These results indicate that ADV and RSV infections in infants differ significantly with regard to the
magnitude of production of interferon-gamma and soluble immune activation markers sCD25 and sTNFR-II.
These immunological differences may be involved in the different clinical outcomes associated with these viral
infections.},
DOI = {}
}