@Article{,
AUTHOR = {Géza Bokodi, András Treszl, László Derzbach, Ádám Balogh, Barna Vásárhelyi},
TITLE = {The association of the carrier state of the tumor necrosis factor-α (TNFα) <sup>-308</sup>A allele with the duration of oxygen supplementation in preterm neonates},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {1},
PAGES = {78--80},
URL = {http://www.techscience.com/ECN/v16n1/66240},
ISSN = {1952-4005},
ABSTRACT = {Background. High levels of inflammatory cytokines lead to lung damage in premature newborns.
We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the
length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the
tumour necrosis factor (TNF)- α G<sup>-308</sup>A, interleukin (IL)-1b C<sup>3954</sup>T, IL-6 G<sup>-174</sup>C and IL-10 G<sup>-1082</sup>A SNPs. Genomic
DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs
and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the
TNF-a G<sup>-308</sup>A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on
average, an additional 36 hours of oxygen supplementation (p=0.0008). The association was significant after its
adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G<sup>308</sup>A genotype – which is
associated with increased TNF-a levels – might influence the supplemental oxygen requirement of VLBW infants.},
DOI = {}
}