TY  - EJOU
AU  - Bokodi, Géza 
AU  - Treszl, András 
AU  - Derzbach, László 
AU  - Balogh, Ádám 
AU  - Vásárhelyi, Barna 

TI  - The association of the carrier state of the tumor necrosis factor-α (TNFα) <sup>-308</sup>A allele with the duration of oxygen supplementation in preterm neonates
T2  - European Cytokine Network

PY  - 2005
VL  - 16
IS  - 1
SN  - 1952-4005

AB  - Background. High levels of inflammatory cytokines lead to lung damage in premature newborns.
We investigated whether single nucleotide polymorphisms (SNP) of innate immunity cytokine genes influence the
length of oxygen supplementation. Methods. We genotyped 123 very low birth weight (VLBW) infants for the
tumour necrosis factor (TNF)- α G<sup>-308</sup>A, interleukin (IL)-1b C<sup>3954</sup>T, IL-6 G<sup>-174</sup>C and IL-10 G<sup>-1082</sup>A SNPs. Genomic
DNA was isolated from remnant dried blood samples from the neonates. We tested the association between SNPs
and ventilation characteristics using a stepwise multiple regression analysis model. Results. The carrier state of the
TNF-a G<sup>-308</sup>A allele was associated with a 40-hour longer period of mechanical ventilation (p=0.004) and, on
average, an additional 36 hours of oxygen supplementation (p=0.0008). The association was significant after its
adjustment for perinatal risk factors for lung damage. Conclusions. The TNF-α G<sup>308</sup>A genotype – which is
associated with increased TNF-a levels – might influence the supplemental oxygen requirement of VLBW infants.
KW  - cytokine
KW  -  genetic polymorphism
KW  -  preterm neonate
KW  -  oxygen supplementation
KW  -  tumour necrosis factor alpha

DO  -