TY  - EJOU
AU  - Numerof, Robert P. 
AU  - Dinarello, Charles A. 
AU  - Asadullah, Khusru 

TI  - Cytokines as potential therapeutic targets for inflammatory skin diseases
T2  - European Cytokine Network

PY  - 2005
VL  - 16
IS  - 2
SN  - 1952-4005

AB  - A network of pro-inflammatory cytokines is a central feature in the pathophysiology of cutaneous
inflammatory diseases. Thus, the delineation of precise roles for particular cytokines and the development of
cytokine-directed therapeutics have become areas of intense investigation. While anti-TNF therapeutics have
proven to be effective for the treatment of psoriasis, clinical investigations have now begun with other
cytokine-directed therapies, such as those targeting IFN-g, IL-12p40, and IL-18. In addition to therapeutics that
target cytokines directly, strategies that target cytokine signaling pathways are in development too. In this short
review, we summarize key findings from a recent workshop on cytokines as potential therapeutic targets for
inflammatory skin diseases.
KW  - cytokines
KW  -  inflammation
KW  -  psoriasis

DO  -