@Article{,
AUTHOR = {F. Hérodin, P. Thullier, D. Garin, M. Drouet},
TITLE = {Nonhuman primates are relevant models for research in hematology, immunology and virology},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {2},
PAGES = {104--116},
URL = {http://www.techscience.com/ECN/v16n2/66222},
ISSN = {1952-4005},
ABSTRACT = {Nonhuman primates have been used for biomedical research for several decades. They have proved
to be models that are relevant to humans because of the high level of gene homology which underlies physiological
and biochemical similarities. The similarity of monkeys to humans has been used to investigate pathophysiological
mechanisms in hematology, immunology and virology. New therapeutic procedures can be assessed in primates by
using materials, in particular pharmacological reagents, and methods designed for humans. The relevance of these
models also relies on the use of species-specific pathogens and the availability of recombinant, homologous
cytokines. The introduction of more and more sophisticated cell and gene therapy protocols in hematopoietic cell
transplantation and immunotherapy requires the development of preclinical trials similar to clinical settings. For
several decades now, baboons and cynomolgus/rhesus monkeys have been the most useful primate models in
experimental hematology, and this has contributed to numerous therapeutic advances. Primate models of AIDS
have been developed to study the pathogenesis, transmission and immune responses to infection, and to test
vaccines and drugs. Primate research should be restricted in quantity, and mainly designed with the aim of
removing uncertainty as to the safety and clinical benefit to the patient, of new biomedical protocols.},
DOI = {}
}