@Article{,
AUTHOR = {Jolanta Myśliwska, K. Zorena, E. Semetkowska-Jurkiewicz, D. Rachoń, H. Suchanek, A. Myśliwski},
TITLE = {High levels of circulating interleukin-10 in diabetic nephropathy patients},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {2},
PAGES = {117--122},
URL = {http://www.techscience.com/ECN/v16n2/66223},
ISSN = {1952-4005},
ABSTRACT = {Aims. The aim of our study was to analyse the level of circulating interleukin-10 (IL-10) and relate
it to the grade of albuminuria in patients with diabetic nephropathy (DN) due to type 1 diabetes mellitus (DM).
Since IL-10 has met the criteria for an anti-inflammatory and an immunosuppressive cytokine, its activity may
be important for clinical outcome of DN. Methods. The IL-10 level was measured by ELISA in serum samples from
thirty patients with DN due to type 1 DM, and compared with thirty patients with type 1 DM without DN and a
control group of thirty, healthy, age- and sex-matched people. Results. We observed a greatly elevated
concentration of circulating IL-10 in 30/30 DM patients with DN (mean 140 pg/mL ± 102), compared to DM
patients without DN in whom IL-10 was detectable in only 11/30 patients (0.79 pg/mL ± 1.24), and the group of
healthy people in whom IL-10 was detectable in only 3/30 donors (0.92 pg/mL ± 0.17). IL-10 appeared to be the
strongest independent predictor of albuminuria, followed by HbA<sub>1</sub>c, diastolic blood pressure and DN duration.
There was a positive correlation between the values of IL-10 and albuminuria in DM patients with DN. The
patients in the fourth quartile of albuminuria had a distinctly higher concentration of IL-10 than those in the
lower quartiles. Conclusions. The increased concentration of IL-10 in the serum samples from DM patients with
DN seems to depend on the severity of the nephropathy. The excessive IL-10 production may indirectly contribute
towards DN progression. On the other hand, it may explain the relatively long course of diabetic nephropathy.},
DOI = {}
}