@Article{,
AUTHOR = {Ettore Capoluongo, Giovanni Vento, Concetta Santonocito, Piero Giuseppe Matassa, Cinzia Vaccarella, Bruno Giardina, Costantino Romagnoli, Cecilia Zuppi, Franco Ameglio},
TITLE = {Comparison of serum levels of seven cytokines in premature newborns undergoing different ventilatory procedures: high frequence oscillatory ventilation or synchronized intermittent mandatory ventilation},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {3},
PAGES = {199--205},
URL = {http://www.techscience.com/ECN/v16n3/66214},
ISSN = {1952-4005},
ABSTRACT = {Objective. The severity of pulmonary dysfunction and subsequent development of chronic lung
disease (CLD) in preterm neonates depends on several factors, among them oxygen administration. The aim of
this report is to compare the effects of high-frequency, oscillatory ventilation (HFOV) versus synchronized,
intermittent, mandatory ventilation (sIMV) on serum cytokine levels (IL-6, IL-8, IL-10, MCP-1, PDGF-BB,
VEGF and TGF-beta1) and ventilator indices during the first week of life. Moreover, CLD development and
several other outcomes were compared between the two groups. Design. Randomized clinical trial. Setting. Third
level NICU. Patients. 40 preterm neonates with a gestational age between 24 and 29 weeks were randomly (20 per
group) assigned to one of the two, above-mentioned ventilation strategies within 30 minutes of birth.
Measurements and results. At 1, 3 and 5 days, neonates were monitored by means of ventilator indices and levels
of seven pro-inflammatory or anti-inflammatory (pro-fibrotic) cytokines in serum. No clinical or biochemical
differences were observed at baseline. The neonates assigned to HFOV benefited from early and sustained
improvement in gas exchange, with earlier extubation and lower incidence of CLD, as compared to the neonates
assigned to sIMV treatment, and showed a significant reduction of serum IL-6, IL-8 and IL-10 over time only
when the HFOV treatment was administered. In addition, at days 3 and 5, the IL-6 levels were significantly lower
in the HFOV group as compared to sIMV patients. Conclusions. The results of this randomized clinical trial
support the hypothesis that early use of HFOV, combined with an optimum volume strategy, has a beneficial effect,
reducing serum levels of pro-inflammatory cytokines and consequently the acute phase leading to lung injury.},
DOI = {}
}