@Article{,
AUTHOR = {Irmeli Roine, J. Alonso Fernandez, Alicia Vásquez, Marianella Cáneo},
TITLE = {Changes in metalloproteinases in healthy normotensive patients with high-normal blood pressure},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {3},
PAGES = {211--214},
URL = {http://www.techscience.com/ECN/v16n3/66216},
ISSN = {1952-4005},
ABSTRACT = {Introduction. High-normal blood pressure (HNBP) seems to be related to increased cardiovascular
risk in healthy, normotensive subjects, while essential hypertension is associated with an increase in extracellular
matrix content, especially fibrillar collagen type I. The aim of our study was to investigate whether collagen
degradation is altered in healthy normotensives with HNBP, and whether this alteration could be related to
disturbances in the matrix metalloproteinases plasma concentration, and to compare the findings to those of
healthy normotensives with normal blood pressure (NBP) levels, matched for age, sex and BMI. Methods. Twenty
six (14 males, 12 females) healthy, normotensive patients with HNBP, mean age 52 ± 5 yrs, and BMI 23 ± 1.5 kg/m<sup>2</sup>
(group A), and 24, healthy normotensive patients (13males, 11females) with NBP, mean age 53 ± 6 yrs, and BMI
23.2 ± 1.4 kg/m<sup>2</sup> (group B), were studied. The two groups were matched for age, sex and BMI. Plasma levels of
matrix metalloproteinase-9 (MMP-9) and tissue inhibitors (TIMP-1) and (TIMP-4) were determined by relevant
ELISA in the study population. Results. Plasma MMP-9 levels were significantly higher, while TIMP-1 and
TIMP-4 levels were significantly lower in group A compared to group B, (MMP-9 579 ± 147 versus 294 ± 111
ng/mL, TIMP-1 178 ± 45 versus 237 ± 35 ng/mL p < 0.01, and TIMP-4 2.2 ± 1.4 versus 4.4 ± 2.1 p < 0.04
respectively). Conclusions. Our findings suggest that healthy normotensives with high-normal blood pressure have
significantly increased MMP-9 and decreased TIMP-1 and TIMP-4 plasma levels compared to healthy
normotensives with normal blood pressure. These findings need further investigation.},
DOI = {}
}