@Article{,
AUTHOR = {Lionel F. Poulin, Claude Habran, Patrick Stordeur, Michel Goldman, Andrew McKenzie, Jacques Van Snick, Jean-Christophe Renauld, Michel Y. Braun},
TITLE = {Interleukin-9 stimulates the production of interleukin-5 in CD4<sup>+</sup> T cells},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {3},
PAGES = {233--239},
URL = {http://www.techscience.com/ECN/v16n3/66219},
ISSN = {1952-4005},
ABSTRACT = {We recently showed that interleukin-9 (IL-9), a Th2 cytokine, promotes IL-5-mediated rejection of
allografts in mice. This observation led us to investigate the functional link between IL-9 and IL-5 production
during alloreactive T cell responses in vitro and in vivo. Firstly, we found that IL-9 was produced by alloreactive
Th2 cells, and IL-9 mRNA was detected in skin allograft during Th2-type rejection. We then established that IL-5
production was impaired in alloreactive Th2 cells isolated from IL-9-deficient mice and that optimal IL-5
production after allogeneic stimulation requires a functional IL-9 receptor (IL-9R) on the responding cells.
Finally, the production of IL-5 by anti-CD3-stimulated CD4<sup>+</sup> T cells was abolished by neutralization of IL-9.
Despite the fact that IL-9 promotes IL-5 production by alloreactive T cells, IL-9-deficient recipients of skin
allografts still developed eosinophilic graft infiltrates and neither IL-9 nor IL-9R deficiency modified Th2-type
allograft rejection.},
DOI = {}
}