@Article{,
AUTHOR = {Katia Boniface, Jean-Claude Lecron, François-Xavier Bernard, Guy Dagregorio, Gérard Guillet, François Nau, Franck Morel},
TITLE = {Keratinocytes as targets for interleukin-10-related cytokines: a putative role in the pathogenesis of psoriasis},
JOURNAL = {European Cytokine Network},
VOLUME = {16},
YEAR = {2005},
NUMBER = {4},
PAGES = {309--319},
URL = {http://www.techscience.com/ECN/v16n4/66209},
ISSN = {1952-4005},
ABSTRACT = {Cytokines are key factors in the cross talk between the immune system and other systems including
hepatic, nervous, cardiac and cutaneous systems, leading to an adaptive and integrated response of the organism
to stress. They are also involved in the regulation of many processes, including hematopoiesis, the immune
response and inflammation. IL-10 is one of the most important anti-inflammatory cytokines. Five cytokines
structurally related to IL-10 have been described and presently form this family of cytokines: IL-19, IL-20, IL-22,
IL-24 and IL-26. In contrast to IL-10, these cytokines display pro-inflammatory activities in different tissues,
including skin. Indeed, some of them induce an inflammatory keratinocyte gene expression profile and an
epidermis histology resembling psoriatic lesions. In this review, we discuss recent knowledge about the effects of
cytokines of the IL-10 family on keratinocytes and their potential role in psoriasis, a cutaneous inflammatory
disease.},
DOI = {}
}