TY  - EJOU
AU  - Cattani, Franca 
AU  - Gallese, Anatolia 
AU  - Mosca, Marco 
AU  - Buanne, Pasquale 
AU  - Biordi, Leda 
AU  - Francavilla, Sandro 
AU  - Coletti, Gino 
AU  - Pellegrini, Luigi 
AU  - Melillo, Gabriella 
AU  - Bertini, Riccardo 

TI  - The role of CXCR2 activity in the contact hypersensitivity response in mice
T2  - European Cytokine Network

PY  - 2006
VL  - 17
IS  - 1
SN  - 1952-4005

AB  - The recruitment of polymorphonuclear neutrophil leukocytes (PMN) into a challenge site, and their
subsequent activation, are thought to play a role in the elicitation of the contact hypersensitivity (CHS) response.
The present study investigated the role played by CXCR2 activity in tissue PMN infiltration and subsequent
triggering of CHS. Our results show that the cutaneous infiltration by PMN, induced by hapten challenge was
dramatically inhibited in sensitized, CXCR2-deficient (CXCR2<sup>-/-</sup>) mice. Inhibition of PMN recruitment into the
hapten-challenged ears of CXCR2<sup>-/-</sup> mice was associated with a consistent reduction of the CHS response (ear
swelling) in CXCR2<sup>-/-</sup> mice as compared with that observed in neutropenic, wild-type (CXCR2<sup>+/+</sup>) mice.
Prevention of skin PMN infiltration and the ear swelling response by the absence of functional CXCR2 was
observed regardless of the hapten used. These data clearly suggest that CXCR2 activity plays an essential role in
mediating cutaneous recruitment and activation of PMN, and thus indirectly regulates recruitment of haptenprimed
T cells into challenge sites, with the subsequent elicitation of the CHS response. The role played by CXCR2
activity in the CHS response provides the rationale for testing CXCR2 inhibitors as a new therapeutic approach
to skin diseases.
KW  - contact hypersensitivity
KW  -  CXCR2
KW  -  PMN recruitment

DO  -