@Article{,
AUTHOR = {Mounir Chennaoui, Catherine Drogou, Charles-Yannick Guezennec, Danielle Gomez-Merino},
TITLE = {Influence of a high carbohydrate diet on the functional activity of 5-HT<sub>1B/1D</sub> receptors on human peripheral blood lymphocytes during intense military training},
JOURNAL = {European Cytokine Network},
VOLUME = {17},
YEAR = {2006},
NUMBER = {1},
PAGES = {67--74},
URL = {http://www.techscience.com/ECN/v17n1/66170},
ISSN = {1952-4005},
ABSTRACT = {The present study was undertaken to examine the effect of a high carbohydrate diet on the
functional activity of 5-HT<sub>1B/1D</sub> receptors in human peripheral blood lymphocytes, and on serum cortisol and
plasma cytokine responses during intense military training. Thirty two male soldiers (mean age: 21 ± 2 years)
were randomly assigned to two groups and received either 3200 kcal/24 h [13440 kJ; habitual diet group (HD)]
or 4200 kcal/24 h [17640 kJ, high carbohydrate diet group (HCD)] by adding 1000 kcal (4200 kJ) of fruit jelly to
the HD. They took part in a three-week training program followed by a five-day combat course. Blood samples
were collected from each group before entry into the commando training and after the five-day combat course.
The results of [<sup>35</sup>S] GTPγS binding assays showed that h5-HT<sub>1B/1D</sub> receptors were desensitized after the training
program in the HD group, whereas no change was observed between the beginning and the end of the military
training in the HCD group [(HD : IC50 = 100 ± 14 nM to 544 ± 178 nM; n = 16) and (HCD: IC50 = 68 ± 14 nM to
101 ± 22 nM; n = 16)]. Serum cortisol was only significantly increased after the commando training in the HD
group (from 532.2 ± 30 to 642 ± 45 nmol·L<sup>-1</sup>, p < 0.05), whereas values were not significantly changed in the HCD
group (441 ± 31 to 502 ± 40 nmol·L-1). No changes were observed in IL-10, TNF-α and IFN-γ levels after the
training program in either group. Carbohydrate ingestion or additional dietary energy during repeated bouts of
high-intensity exercise could attenuate the alterations in immune function via 5-HT<sub>1B/1D</sub> receptors and the action
of 5-HT moduline, an endogenous tetrapeptide (Leu-Ser-Ala-Leu) that specifically modulates the sensitivity of
5-HT<sub>1B/1D</sub> receptors.},
DOI = {}
}