@Article{,
AUTHOR = {Ali Akbar Amirzargar, Nima Rezaei, Hossein Jabbari, Abdol-Ali Danesh, Farideh Khosravi, Mahboubeh Hajabdolbaghi, Alireza Yalda, Behrouz Nikbin},
TITLE = {Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis},
JOURNAL = {European Cytokine Network},
VOLUME = {17},
YEAR = {2006},
NUMBER = {2},
PAGES = {84--89},
URL = {http://www.techscience.com/ECN/v17n2/66153},
ISSN = {1952-4005},
ABSTRACT = {Background. Several genes coding for different cytokines may affect host susceptibility totuberculosis. Methods. In the present study, the allele and genotype frequencies of a number polymorphic genescoding for cytokines or cytokine receptors were investigated in Iranian patients with pulmonary tuberculosis(PTB). Results. From the IL-1 cluster, a positive, significant difference was found at position -889, where the T/Tgenotype was over represented in PTB patients (p = 0.01); a positive, significant increase was found in the IL1RPstI 1970 C/C genotype, where the C allele was over represented in the PTB patients (p = 0.01). A significantnegative association at codon 10 TGF-β, T allele, was shown in our patients and the C allele and C/C genotypewere over represented in the PTB patients (P<0.005). For TNF-α at position -238, we found a negative associationfor the G/Agenotype and a positive association for the G/G genotype (p = 0.0009). Significant negative associationsat position -590 IL-4, T allele and the T/T genotype were shown in our patients (p = 0.0007); also, the C allele andT/C genotype were significantly increased in our patients (P<0.05). With IL-6 at -174, G/G increased and G/Cdecreased significantly in the patients (P<0.005). Conclusion. Pro-inflammatory cytokines such as TNF-α andTGF-β seem to be decreased, and IL-6 increased in PTB patients.},
DOI = {}
}