TY  - EJOU
AU  - Amirzargar, Ali Akbar 
AU  - Rezaei, Nima 
AU  - Jabbari, Hossein 
AU  - Danesh, Abdol-Ali 
AU  - Khosravi, Farideh 
AU  - Hajabdolbaghi, Mahboubeh 
AU  - Yalda, Alireza 
AU  - Nikbin, Behrouz 

TI  - Cytokine single nucleotide polymorphisms in Iranian patients with pulmonary tuberculosis
T2  - European Cytokine Network

PY  - 2006
VL  - 17
IS  - 2
SN  - 1952-4005

AB  - Background. Several genes coding for different cytokines may affect host susceptibility totuberculosis. Methods. In the present study, the allele and genotype frequencies of a number polymorphic genescoding for cytokines or cytokine receptors were investigated in Iranian patients with pulmonary tuberculosis(PTB). Results. From the IL-1 cluster, a positive, significant difference was found at position -889, where the T/Tgenotype was over represented in PTB patients (p = 0.01); a positive, significant increase was found in the IL1RPstI 1970 C/C genotype, where the C allele was over represented in the PTB patients (p = 0.01). A significantnegative association at codon 10 TGF-β, T allele, was shown in our patients and the C allele and C/C genotypewere over represented in the PTB patients (P<0.005). For TNF-α at position -238, we found a negative associationfor the G/Agenotype and a positive association for the G/G genotype (p = 0.0009). Significant negative associationsat position -590 IL-4, T allele and the T/T genotype were shown in our patients (p = 0.0007); also, the C allele andT/C genotype were significantly increased in our patients (P<0.05). With IL-6 at -174, G/G increased and G/Cdecreased significantly in the patients (P<0.005). Conclusion. Pro-inflammatory cytokines such as TNF-α andTGF-β seem to be decreased, and IL-6 increased in PTB patients.
KW  - cytokine gene
KW  -  Iran
KW  -  polymorphisms
KW  -  pulmonary tuberculosis

DO  -