@Article{,
AUTHOR = {Thomas Makris, Georgios Stavroulakis, Demetrios Papadopoulos, Ioannis Paizis, Panagiota Krespi, Caterina Tsoukala, Antonios Hatzizacharias, Vasilios Votteas},
TITLE = {White coat hypertension and haemostatic/fibrinolytic balance disorders},
JOURNAL = {European Cytokine Network},
VOLUME = {17},
YEAR = {2006},
NUMBER = {2},
PAGES = {137--141},
URL = {http://www.techscience.com/ECN/v17n2/66160},
ISSN = {1952-4005},
ABSTRACT = {White coat hypertension (WCH) or isolated clinic hypertension is generally accepted to be a benign
condition, although some reports have suggested that it may be associated with an increased cardiovascular event
rate or other cardiovascular alterations. It has been previously shown that essential hypertension (EH) is
associated with abnormalities in haemostatic/fibrinolytic balance and endothelial function. The aim of our study
was to assess the impact of WCH on fibrinolytic balance and endothelial function by measuring plasma levels of
plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA), fibrinogen, and thrombomodulin.
These markers were determined in 71 patients with EH, 26 with WCH and 87 normotensive healthy
control subjects. The three groups were not different with respect to age, gender, smoking habits, BMI and blood
lipids. Subjects with WCH were found to have increased plasma levels of PAI-1, tPA, fibrinogen and
thrombomodulin compared to controls, but less compared to hypertensive ones. Our results suggest that WCH
may be associated with decreased fibrinolytic potential and endothelial dysfunction, indicating that WCH may not
be a completely harmless trait.},
DOI = {}
}