@Article{ecn.2006.0031,
AUTHOR = {Susanne Schulz, Undraga Schagdarsurengin, Dirk Rehfeld, Thomas Süß, Karl Werdan, Ursula Müller-Werdan, Christiane Gläser},
TITLE = {Genetic impact of TNF-β on risk factors for coronary atherosclerosis},
JOURNAL = {European Cytokine Network},
VOLUME = {17},
YEAR = {2006},
NUMBER = {3},
PAGES = {148--154},
URL = {http://www.techscience.com/ECN/v17n3/66144},
ISSN = {1952-4005},
ABSTRACT = {Background. Inflammatory processes are considered to play an important role in the development
of coronary atherosclerosis. The proinflammatory cytokine, tumor necrosis factor b (TNF-β), is thought to
contribute to the pathogenesis of atherosclerosis. Study design. In this clinical study, the influence of genetic
variants of TNF-β (c.7G>A, IVS1+90G>A, C13R, T60N) on major coronary risk factors, including gender,
smoking, history of cardiovascular diseases, biochemical data (inflammatory markers, factors of lipid metabolism,
coagulation/fibrinolysis balance), and angiographically-proven coronary state, was investigated in 176 European
Caucasian probands (130 males, mean age: 51.9 ± 8.9 y). Results. The most frequent combinations of the
polymorphisms investigated were significantly associated with four of the coronary risk factors evaluated:
hypertension, body mass index, the common inflammatory marker TNF-α (mRNA expression), and fibrinogen (p
< 0.05). However, on testing the impact of the genetic background on the incidence of coronary stenosis in this
sample of European Caucasians, no significant influence of these polymorphisms (stepwise binary logistic
regression analysis) could be proven. These findings emphasise a distinct influence of TNF-β polymorphisms on
important modulators of the development of coronary atherosclerosis, but exclude its genetic background,
investigated in this study as an independent coronary risk factor.},
DOI = {10.1684/ecn.2006.0031}
}