TY  - EJOU
AU  - Lavens, Delphine 
AU  - Piessevaux, Julie 
AU  - Tavernier, Jan 

TI  - Review: negative regulation of leptin receptor signalling
T2  - European Cytokine Network

PY  - 2006
VL  - 17
IS  - 3
SN  - 1952-4005

AB  - Leptin was discovered as an adipostat, regulating body weight by balancing food intake and energy
expenditure. Recently, leptin emerged as a pleiotropic cytokine. It plays a substantial role in a wide spectrum of
other functions including immune regulation, bone formation and fertility. Leptin signalling is under tight control.
Aberrations of this stringent control system may be implicated in a variety of pathologies. Here, we review the
various mechanisms that control cellular leptin receptor signalling.
KW  - leptin receptor signalling
KW  -  negative regulation
KW  -  SHP-2
KW  -  PTP1B
KW  -  SOCS proteins

DO  - 10.1684/ecn.2006.0040