TY  - EJOU
AU  - Torbé, Andrzej 
AU  - Czajka, Ryszard 
AU  - Kordek, Agnieszka 
AU  - Rzepka, Rafał 
AU  - Kwiatkowski, Sebastian 
AU  - Rudnicki, Jacek 

TI  - Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations
T2  - European Cytokine Network

PY  - 2007
VL  - 18
IS  - 2
SN  - 1952-4005

AB  - Our aim was to compare maternal serum concentrations of interleukin(IL)-1α IL-1β, IL-6 and IL-8
in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at approximately full-term,
and to determine if these assays have any value in the prediction of early-onset neonatal infection or histological
chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy controls.
Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL; p = 0.002) and IL-1β (2.20 versus 0.50 pg/mL;
p = 0.003) were significantly higher in patients with PTL as compared to healthy pregnant women. The IL-1β
concentration (13.60 versus 1.20 pg/mL; p = 0.02) was significantly higher in the serum of mothers whose babies
developed early-onset infections, than in mothers of newborns that were healthy. However, its predictive value,
and the value of the other cytokines studied, was poor. In addition, IL-1β levels (28.79 versus 5.19 pg/mL;
p = 0.001) were significantly higher in patients with histological chorionamnionitis, than in those without the
condition,. The cut-off value of ≥ 14 pg/mL predicted inflammatory changes with a sensitivity of 80%, specificity
of 86%, PPV of 80% and NPV of 86%. IL-1β seems to be of moderate value in the prediction of histological
chorioamnionitis.
KW  - cytokine
KW  -  histological chorioamnionitis
KW  -  infection
KW  -  maternal serum
KW  -  preterm labor

DO  - 10.1684/ecn.2007.0092