@Article{ecn.2007.0092,
AUTHOR = {Andrzej Torbé, Ryszard Czajka, Agnieszka Kordek, Rafał Rzepka, Sebastian Kwiatkowski, Jacek Rudnicki},
TITLE = {Maternal serum proinflammatory cytokines in preterm labor with intact membranes: neonatal outcome and histological associations},
JOURNAL = {European Cytokine Network},
VOLUME = {18},
YEAR = {2007},
NUMBER = {2},
PAGES = {102--107},
URL = {http://www.techscience.com/ECN/v18n2/66002},
ISSN = {1952-4005},
ABSTRACT = {Our aim was to compare maternal serum concentrations of interleukin(IL)-1α IL-1β, IL-6 and IL-8
in pregnancies complicated by preterm labor (PTL), with the levels in healthy controls at comparable gestational
age, and to determine if these assays have any value in the prediction of early-onset neonatal infection or
histological chorioamnionitis. The study population consisted of 65 women with new-onset PTL, and 31 healthy
controls. Maternal serum concentrations of IL-6 (8.40 versus 3.30 pg/mL; p = 0.002) and IL-1β (2.20 versus 0.50
pg/mL; p = 0.003) were significantly higher in patients with PTL as compared to healthy pregnant women. The
IL-1β concentration (13.60 versus 1.20 pg/mL; p = 0.02) was significantly higher in the serum of mothers whose
babies developed early-onset infections, than in mothers of newborns that were healthy. However, its predictive
value, and the value of the other cytokines studied, was poor. In addition, IL-1β levels (28.79 versus 5.19 pg/mL;
p = 0.001) were significantly higher in patients with histological chorionamnionitis, than in those without the
condition,. The cut-off value of ≥ 14 pg/mL predicted inflammatory changes with a sensitivity of 80%, specificity
of 86%, PPV of 80% and NPV of 86%. IL-1β seems to be of moderate value in the prediction of histological
chorioamnionitis.},
DOI = {10.1684/ecn.2007.0092}
}