@Article{ecn.2007.0103,
AUTHOR = {Ewa Robak, Lilianna Kulczycka, Anna Sysa-JVdrzejowska, Agnieszka Wierzbowska, Tadeusz Robak},
TITLE = {Circulating proangiogenic molecules PIGF, SDF-1 and sVCAM-1 in patients with systemic lupus erythematosus},
JOURNAL = {European Cytokine Network},
VOLUME = {18},
YEAR = {2007},
NUMBER = {4},
PAGES = {9--15},
URL = {http://www.techscience.com/ECN/v18n4/65961},
ISSN = {1952-4005},
ABSTRACT = {Serum concentrations of three angiogenic cytokines: vascular endothelial growth factor (VEGF),
stromal cell-derived factor-1 (SDF-1) and placental growth factor (PIGF) and soluble vascular cell adhesion
molecule 1 (sVCAM-1), were investigated in the serum of 61 patients with systemic lupus erythematosus (SLE)
and 20 healthy subjects. The possible association between serum levels of these proteins and SLE activity, as well
as correlation between the concentrations of cytokines were also analysed. All of these factors were detectable in
all SLE patients and the healthy control group. The median concentration of VEGF was higher in active SLE (386
pg/mL) than in inactive disease (327 pg/mL) or in the control group (212 pg/mL, p < 0.004). The median serum
level of SDF-1 was higher in SLE patients (1814 pg/ml) than in the control group (1507 pg/mL, p < 0.02). The
median concentration of PIGF was higher (14 pg/mL) in SLE patients than in the control group (12 pg/mL,
p = 0.03), and particularly in active disease (17 pg/mL) as compared to the inactive phase (13 pg/mL, p = 0.01).
The correlations between the levels of cytokines examined and clinical features, laboratory abnormalities and the
type of treatment were also analysed. We found a positive correlation between serum concentrations of PIGF and
SLE activity according to SLAM score (p = 0.33, p=0.13).},
DOI = {10.1684/ecn.2007.0103}
}