@Article{ecn.2007.0105,
AUTHOR = {Pierre-Blaise Matsiegui, Michel A. Missinou, Saadou Issifou, Magdalena Necek, Elie Mavoungou},
TITLE = {Ibuprofen does not affect levels of tumor necrosis factor-a and soluble tumor necrosis factor receptor types I and II in Gabonese children with uncomplicated <i>Plasmodium falciparum</i> malaria},
JOURNAL = {European Cytokine Network},
VOLUME = {18},
YEAR = {2007},
NUMBER = {4},
PAGES = {23--27},
URL = {http://www.techscience.com/ECN/v18n4/65963},
ISSN = {1952-4005},
ABSTRACT = {We assessed the ability of ibuprofen to modulate tumor necrosis factor-α (TNF-α), soluble tumor
necrosis factor receptor type I (sTNFR-I), and soluble tumor necrosis factor receptor type II (sTNFR-II) responses
during the treatment of fever in uncomplicated <i>Plasmodium falciparum</i> malaria, in a placebo-controlled,
randomized, double-blind study of 50 pediatric patients in Lambaréné, Gabon. Treatment of the malaria involved
the patients receiving intravenous quinine (12 mg/kg of quinine dihydrochloride every 12 h for 72 h) followed by
a single dose of oral sulfadoxine/pyrimethamine (25 mg and 1.25 mg/kg). Fever was treated by mechanical
treatment plus either ibuprofen (7 mg/kg every 8 hours) or placebo during the hospitalization period. We
determined serum concentrations of TNF-α, sTNFR-I, and sTNFR-II in peripheral blood throughout the
treatment period in the two groups: ibuprofen and placebo groups. TNF-α levels were found to be positively
correlated with body temperature. In contrast, TNF receptors levels did not differ between the two groups and the
antipyretic effect of ibuprofen was not correlated with specific changes in sTNFR-I and sTNFR-II production. Our
data suggest that TNF-α is involved in malarial fever, but soluble TNF receptors play no major role in fever
modulation.},
DOI = {10.1684/ecn.2007.0105}
}