@Article{ecn.2007.0112,
AUTHOR = {Kyriaki Venetsanou, Konstantinos Vlachos, Athanassios Moles, Gerassimos Fragakis, George Fildissis, George Baltopoulos},
TITLE = {Hypolipoproteinemia and hyperinflammatory cytokines in serum of severe and moderate traumatic brain injury (TBI) patients},
JOURNAL = {European Cytokine Network},
VOLUME = {18},
YEAR = {2007},
NUMBER = {4},
PAGES = {206--209},
URL = {http://www.techscience.com/ECN/v18n4/65972},
ISSN = {1952-4005},
ABSTRACT = {Traumatic brain injury (TBI) acts as an inducer of the inflammatory reaction expressed by the
release of pro-inflammatory cytokines (interleukin-1b [IL-1b], interleukin-6 [IL-6] and interleukin-8 [IL-8]), and
causes metabolic alterations in the early, post-traumatic state, either in the brain or/and the systemic circulation.
The metabolic changes involve carbohydrates, proteins and lipids. We focused on the serum lipid profile, the
impact of trauma on lipoproteins, and their subsequent effects, on inflammation. We investigated the role of
cytokines and serum lipids, in patient outcome, reviewing 30-day mortality and the Glasgow Coma Scale (GCS).
A total of 75 patients with severe or moderate TBI (GCS ≤ 13) were allocated to two groups (group 1 non-survivors
and group 2 survivors). One blood sample was collected from each patient within 24h of admission. Cytokines
were measured in serum by ELISA and serum lipids using an enzymatic method. We found significantly decreased
serum lipid levels and increased cytokines levels for all patients compared with healthy volunteers. Comparing the
two groups, IL-6 and IL-8 levels were higher (p < 0.0001) and LDL levels lower (p = 0.003) in non-survivors than
in survivors. We observed a significant inverse correlation between IL-8 and LDL (p = 0.04) in patients with an
unfavorable outcome. Our results suggest that LDL alone, or in combination with IL-6 and IL-8, could be a
possible prognostic factor for outcome in patients with TBI, as regards 30- day mortality.},
DOI = {10.1684/ecn.2007.0112}
}