@Article{ecn.2008.0119,
AUTHOR = {Ozer Soylu, Aydin Yildirim, Ajda Coker, Tuna Tezel, Edward O. List, Ahmet Arman},
TITLE = {Interleukin-1B (-511) gene polymorphism is associated with acute coronary syndrome in the Turkish population},
JOURNAL = {European Cytokine Network},
VOLUME = {19},
YEAR = {2008},
NUMBER = {1},
PAGES = {42--48},
URL = {http://www.techscience.com/ECN/v19n1/65947},
ISSN = {1952-4005},
ABSTRACT = {Objectives: acute coronary syndrome (ACS) is defined as an inflammatory disease associated with
development of atherosclerosis and instability. IL-1 is a candidate inflammatory cytokine that is thought to trigger
ACS. The purpose of this study was to determine the relationship between IL-1 gene family polymorphisms
(IL-1RN, IL-1B in positions -511 and +3953) and ACS in the Turkish population. Methods: a total of 381 people
participated in the study, with 117 control subjects and 264 ACS patients. Of the 264 ACS patients, 112 were
diagnosed with stable angina pectoris (SAP) and 152 were diagnosed with unstable angina pectoris (USAP). The
polymerase chain reaction (PCR) was used to determine the genotype of IL-1RN. The genotypes of IL-1B (-511
and +3953) were determined by PCR, followed by restriction enzyme digestion of the PCR products. Results: there
were no significant differences in both IL-1RN, IL-1B (-511 and +3953) genotype distributions and IL-1RN allele
frequencies between ACS patients and the control subjects. In addition, no association was observed in the allele
frequency of IL-1B (-511 and +3953) between ACS patients and controls (p = 0.113 and p = 0.859, respectively),
or between SAP patients and controls (p = 0.575 and p = 0.359, respectively). However, IL-1B allele 1 (C) (-511)
polymorphism in USAP patients was found to be significantly different from that of control subjects (p = 0.041,
OR: 2.01; 95% CI: 1.985-3.933). A significant difference was also observed between USAP and SAP patients for
IL-1B (+3953) allele 1 (C) polymorphism; (p = 0.043, OR: 1.522; 95% CI: 1.012-2.88). Conclusion: these results
show that IL-1RN gene polymorphism has no association with ACS. However, the allele 1 (C) of IL-1B (-511) may
be a risk factor for susceptibility to USAP in the Turkish population.},
DOI = {10.1684/ecn.2008.0119}
}