@Article{ecn.2008.0123,
AUTHOR = {Alicja Kasperska-Zajac, Zenon Brzoza, Barbara Rogala},
TITLE = {Increased concentration of platelet-derived chemokines in serum of patients with delayed pressure urticaria},
JOURNAL = {European Cytokine Network},
VOLUME = {19},
YEAR = {2008},
NUMBER = {2},
PAGES = {89--91},
URL = {http://www.techscience.com/ECN/v19n2/65937},
ISSN = {1952-4005},
ABSTRACT = {Background. Delayed pressure urticaria (DPU) is a distinct form of urticaria, characterized by
marked dermal swelling, deep inflammatory infiltrate and systemic symptoms. Little is known about inflamma-tory
mediators involved in this disease. Objective. To investigate secretion of platelet-specific chemokines, platelet
factor 4 (PF-4) and beta-thromboglobulin (beta-TG) during the course of DPU. Methods and material. Plasma
concentrations of PF-4 and beta-TG were measured in eight adult DPU patients and in 15, age- and sex-matched,
healthy controls. Results. Plasma PF-4 and beta-TG concentration scores were significantly higher in the DPU
group as compared with the control subjects. Conclusion. The present study, as well as an earlier contribution,
suggest that distinct platelet activity may be identified in different types of urticaria. In contrast to chronic
idiopathic urticaria, chronic urticaria with a positive response to autologous serum skin testing, and acute
urticaria, delayed pressure urticaria may be associated with increased secretion of platelet chemokines, similar to
that observed in cold urticaria.},
DOI = {10.1684/ecn.2008.0123}
}