TY  - EJOU
AU  - Amirzargar, Ali Akbar 
AU  - Naroueynejad, Mehrnaz 
AU  - Khosravi, Farideh 
AU  - Dianat, Saied 
AU  - Rezaei, Nima 
AU  - Mytilineos, Joannis 
AU  - Nikbin, Behrouz 

TI  - Cytokine single nucleotide polymorphisms in Iranian populations
T2  - European Cytokine Network

PY  - 2008
VL  - 19
IS  - 2
SN  - 1952-4005

AB  - Cytokines are important immunomodulatory molecules involved in immune responses against
microorganisms; they also have an important role in the setting of immune system disorders. Cytokine single
nucleotide polymorphisms have been extensively studied in different, normal populations as well as in association
with disease. Cytokine gene polymorphisms are potentially important as genetic predictors of disease suscepti-bility,
clinical outcome, and as a tool for anthropological studies. In this study, samples have been collected from
455 healthy individuals located in different regions of Iran (Tehran, Yazd, Sistan and Balochistan). Allele and
genotype frequencies of cytokine SNP, including: IL-1α, IL-1β, IL-1R, IL-1RA, IL-2, IL-4, IL-4RA, IL-6, IL-10,
IL-12, TNF-α, TGF-β and IFN-γ were investigated, using the PCR-SSP method. Allele frequencies in Tehran and
Yazd populations were similar, except for TGF-b. Allele frequencies in Sistani & Baloch populations were similar
at all positions, except for IL-β at position of -511 and IFN-γ genes at position UTR5644; there were some
differences in allele frequencies comparing these populations with the Yazd population, including: IL-4, IL-6,
IL-10, TGF-β and TNF-α. Although some significant differences were observed for some cytokines, it seems that
the cytokine gene polymorphism profile of the Iranian population is similar to that of Caucasians, particularly the
Italian population.
KW  - cytokine gene
KW  -  Iran
KW  -  polymorphisms

DO  - 10.1684/ecn.2008.0122