@Article{ecn.2009.0141,
AUTHOR = {Herbert Tilg, Alexander R. Moschen, Arthur Kaser},
TITLE = {Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {1},
PAGES = {1--6},
URL = {http://www.techscience.com/ECN/v20n1/65910},
ISSN = {1952-4005},
ABSTRACT = {Type I interferons (IFNs) are the first line of defence after various infections, and, as immuno-modulatory
cytokines, bridge innate and adaptive immunity. IL-17, mainly secreted by specific T cells, has
recently been identified regulating neutrophil-mediated inflammation, and has been implicated in the pathogen-esis
of many acute and chronic inflammatory disorders. This cytokine is considered of critical importance for
an effective anti-bacterial and anti-fungal immune response as needed subsequent to many viral infections.
Recent studies have demonstrated that type I IFNs potently suppress IL-17 expression and Th17 differentiation
in vitro and in vivo. Therefore, suppression of IL-17, as well as many other well-defined interactions of type I
IFNs with the cytokine cascade, may contribute to virus-induced immunosuppression making the host vulnera-ble
to bacterial and fungal attacks.},
DOI = {10.1684/ecn.2009.0141}
}