TY  - EJOU
AU  - Tilg, Herbert 
AU  - Moschen, Alexander R. 
AU  - Kaser, Arthur 

TI  - Suppression of interleukin-17 by type I interferons: a contributing factor in virus-induced immunosuppression?
T2  - European Cytokine Network

PY  - 2009
VL  - 20
IS  - 1
SN  - 1952-4005

AB  - Type I interferons (IFNs) are the first line of defence after various infections, and, as immuno-modulatory
cytokines, bridge innate and adaptive immunity. IL-17, mainly secreted by specific T cells, has
recently been identified regulating neutrophil-mediated inflammation, and has been implicated in the pathogen-esis
of many acute and chronic inflammatory disorders. This cytokine is considered of critical importance for
an effective anti-bacterial and anti-fungal immune response as needed subsequent to many viral infections.
Recent studies have demonstrated that type I IFNs potently suppress IL-17 expression and Th17 differentiation
in vitro and in vivo. Therefore, suppression of IL-17, as well as many other well-defined interactions of type I
IFNs with the cytokine cascade, may contribute to virus-induced immunosuppression making the host vulnera-ble
to bacterial and fungal attacks.
KW  - type I interferon
KW  -  Th17 cells
KW  -  mononuclear cells
KW  -  IL-10
KW  -  viral infection

DO  - 10.1684/ecn.2009.0141