TY  - EJOU
AU  - Trouillas, Marina 
AU  - Saucourt, Claire 
AU  - Guillotin, Bertrand 
AU  - Gauthereau, Xavier 
AU  - Taupin, Jean-Luc 
AU  - Moreau, Jean-François 
AU  - Bœuf, Hélène 

TI  - The LIF cytokine: towards adulthood
T2  - European Cytokine Network

PY  - 2009
VL  - 20
IS  - 2
SN  - 1952-4005

AB  - The aim of this article is to recapitulate the key features of leukaemia inhibitory factor cytokine
(LIF), to review its numerous physiological effects and to comment on the most recent data. We will also pres-ent
results of transcriptome analyses, which have highlighted different categories of LIF targets, identified in
murine embryonic stem (ES) cells and early derivatives. We hope to stimulate new research fields on this puz-zling
cytokine, which, forty years after its discovery, has still not disclosed all its secrets.
KW  - LIF
KW  -  IL-6
KW  -  ES cells
KW  -  pleiotropy
KW  -  chromatin
KW  -  p53<sup>1</sup>

DO  - 10.1684/ecn.2009.0148