@Article{ecn.2009.0154,
AUTHOR = {Manel Amri, Dalila Mezioug, Chafia Touil-Boukoffa},
TITLE = {Involvement of IL-10 and IL-4 in evasion strategies of <i>Echinococcus granulosus</i> to host immune response},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {2},
PAGES = {63--68},
URL = {http://www.techscience.com/ECN/v20n2/65904},
ISSN = {1952-4005},
ABSTRACT = {Human echinococcosis is one of the world’s major zoonotic infections. In this study, our aim is to
clarify one of the strategies used by the parasite for evasion and prolonged infestation in the host. We wished to
provide further immunological evidence for the involvement of IL-10/IL-4 in these mechanisms. In this regard,
we investigated the effects of IL-4 and IL-10 on protoscoleces (PSC: the larval form of the parasite), co-cultured
with patient PBMC. Furthermore, we used IL-4 and IL-10 antibodies to confirm this effect. Our
results showed that IL-4 and IL-10 reduced PSC killing. This reduction correlates with an decrease in NO pro-duction
by PBMC. In conclusion, the results reported here suggest that IL-4/IL-10 impairs the Th1 protective
response and allows the parasite to survive in hydatid patients.},
DOI = {10.1684/ecn.2009.0154}
}