@Article{ecn.2009.0157,
AUTHOR = {Muriel Tahtouh, Françoise Croq, Christophe Lefebvre, Joël Pestel},
TITLE = {Is complement good, bad, or both? New functions of the complement factors associated with inflammation mechanisms in the central nervous system},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {3},
PAGES = {95--100},
URL = {http://www.techscience.com/ECN/v20n3/65893},
ISSN = {1952-4005},
ABSTRACT = {The complement system is well known as an enzyme cascade that helps to defend against infec-tions.
Indeed, this ancestral system bridges innate and adaptive immunity. Its implication in diseases of the cen-tral
nervous system (CNS), has led to an increased number of studies. Complement activation in the CNS has
been generally considered to contribute to tissue damage. However, recent studies suggest that complement
may be neuroprotective, and can participate in maintenance and repair of the adult brain. Here, we will review
this dual role of complement proteins and some of their functional interactions with part of the chemokine and
cytokine network associated with the protection of CNS integrity.},
DOI = {10.1684/ecn.2009.0157}
}