@Article{ecn.2009.0161,
AUTHOR = {Bozena Dobrzycka, Slawomir J. Terlikowski, Oksana Kowalczuk, Maciej Kinalski},
TITLE = {Circulating levels of TNF-α and its soluble receptors in the plasma of patients with epithelial ovarian cancer},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {3},
PAGES = {131--134},
URL = {http://www.techscience.com/ECN/v20n3/65898},
ISSN = {1952-4005},
ABSTRACT = {The significance of circulating levels of TNF-α and its soluble receptors (sTNF-Rs) in the plasma
of patients with epithelial ovarian cancer (EOC) has not been fully elucidated. The present study was to investi-gate
the relationship of pretreatment plasma levels of TNF-α, sTNFR-1 and sTNFR-2 with outcome in
126 patients with EOC. Concentrations of TNF-α and sTNF-Rs were determined by enzyme-linked immunosor-bent
assay (ELISA). Median TNF-α and sTNF-Rs levels were significantly higher in EOC patients than in
healthy controls. High plasma levels of TNF-α and sTNF-Rs were correlated with tumor stage and with reduced
mean survival time (MST). The results of the present study suggested that preoperative plasma TNF-α and
sTNF-Rs levels in EOC patients correlated with the highest risk of cancer progression. Thus, the clinical value
of an activated TNF system in EOC needs to be further investigated.},
DOI = {10.1684/ecn.2009.0161}
}