@Article{ecn.2009.0160,
AUTHOR = {Bartosz Hudzik, Janusz Szkodzinski, Wojciech Romanowski, Krzysztof Wilczek, Rafal Wojnar, Andrzej Lekston, Lech Polonski, Barbara Zubelewicz-Szkodzinska},
TITLE = {No predictive value of serum interleukin-6 and transforming growth factor-β1 in identifying patients with a first restenosis, recurrent restenosis or a history of restenosis},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {3},
PAGES = {135--139},
URL = {http://www.techscience.com/ECN/v20n3/65899},
ISSN = {1952-4005},
ABSTRACT = {Background. The efficacy of percutaneous coronary intervention (PCI) is limited by the need for
repeat revascularization resulting from restenosis. The restenosis rate after treatment for in-stent restenosis
(recurrent restenosis) is high (> 30%). Numerous studies have suggested the predictive value of interleukin 6
(IL-6) and transforming growth factor β1 (TGF-β1). Methods. We sought to determine whether serum levels of
IL-6 and TGF-β1 could help identify individuals with recurrent restenosis. Thirty seven patients with a history
of stent implantation were enrolled and divided into three groups: (1) patients with a current, first restenosis
(n = 9); (2) patients with current restenosis and at least one prior restenosis (recurrent restenosis) (n = 11), and
(3) patients with a history of restenosis, but without current restenosis (n = 17). Results. The baseline profile
was similar in all three groups. The median (25<sup>th</sup>
-75<sup>th</sup> percentile) concentrations of IL-6 were: group 1 – 2.8
(1.4-5.5); group 2 – 2.6 (0.6-8.6); group 3 – 2.4 (0.9-4.7) p = 0.69 and TGF-β1: group 1 – 3.6 (0.2-14.4); group 2
– 4.2 (1.8-57.6); group 3 – 6.6 (2.8-30.0) p = 0.57. Moreover we found no correlation, either between diameter
stenosis and IL-6 (R = 0.10; p = 0.38) or TGF-β1 (R = 0.10; p = 0.57). Both IL-6 (AUC 0.59 p = 0.4 and AUC
0.51 p = 0.9) and TGF-β1 (AUC 0.64 p = 0.2 and AUC 0.50 p = 0.9) failed to provide significant results in
receiver-operating characteristic analysis. Conclusion. We report that there is no association between the severity
of diameter stenosis (restenosis) and IL-6 or TGF-β1 concentrations. Our findings might suggest that levels of
IL-6 and TGF-β1 have no predictive value for identifying patients with recurrent restenosis.},
DOI = {10.1684/ecn.2009.0160}
}