@Article{ecn.2009.0158,
AUTHOR = {Emiliana Finamore, Mariateresa Vitiello, Marina D’Isanto, Emilia Galdiero, Annarita Falanga, Aikaterini Kampanaraki, Katia Raieta, Marilena Galdiero},
TITLE = {Evidence for IL-6 promoter nuclear activation in U937 cells stimulated with <i>Salmonella enterica</i> serovar Typhimurium porins},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {3},
PAGES = {140--147},
URL = {http://www.techscience.com/ECN/v20n3/65900},
ISSN = {1952-4005},
ABSTRACT = {Interleukin-6 (IL-6) is a pleiotropic cytokine and plays an active role in inflammatory and
immune responses, contributing to a multitude of physiological and pathophysiological processes. In this study,
we address the molecular mechanism of IL-6 transcriptional induction and propose a correlation between acti-vated
NF-κB localization and IL-6 expression. In particular, we detected, by ChIP assay, that occupation of the
IL-6 gene promoter site is dependent on activated NF-κB. In fact, after porin stimulation, the NF-κB p65 sub-unit
is activated, translocates to the nucleus and binds to the IL-6 promoter sequence.Elucidation of the host
signaling pathways and identification of the transcription factors that contribute to IL-6 expression, may aid in
the understanding of host susceptibility to gram-negative infections and in identifying new therapeutic strategies
in a variety of infectious diseases.},
DOI = {10.1684/ecn.2009.0158}
}