@Article{ecn.2009.0170,
AUTHOR = {Napoleone Ferrara},
TITLE = {VEGF-A: a critical regulator of blood vessel growth},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {4},
PAGES = {158--163},
URL = {http://www.techscience.com/ECN/v20n4/65884},
ISSN = {1952-4005},
ABSTRACT = {Angiogenesis is required for a variety of normal and pathological, proliferative processes. Numer-ous
regulators of angiogenesis have been identified and characterized over the last decades. Among these, vas-cular
endothelial growth factor (VEGF)-A appears especially important in normal development and in disease
processes. Several VEGF inhibitors have been approved by the FDA for the treatment of tumors or the neovas-cular
form of age-related macular degeneration. This article examines the molecular and biological characteris-tics
of VEGF and also discusses preclinical and clinical studies with VEGF inhibitors and the lessons learned
from these studies.},
DOI = {10.1684/ecn.2009.0170}
}