TY  - EJOU
AU  - Ferrara, Napoleone 

TI  - VEGF-A: a critical regulator of blood vessel growth
T2  - European Cytokine Network

PY  - 2009
VL  - 20
IS  - 4
SN  - 1952-4005

AB  - Angiogenesis is required for a variety of normal and pathological, proliferative processes. Numer-ous
regulators of angiogenesis have been identified and characterized over the last decades. Among these, vas-cular
endothelial growth factor (VEGF)-A appears especially important in normal development and in disease
processes. Several VEGF inhibitors have been approved by the FDA for the treatment of tumors or the neovas-cular
form of age-related macular degeneration. This article examines the molecular and biological characteris-tics
of VEGF and also discusses preclinical and clinical studies with VEGF inhibitors and the lessons learned
from these studies.
KW  - VEGF
KW  -  VPF
KW  -  angiogenesis
KW  -  tumor

DO  - 10.1684/ecn.2009.0170