@Article{ecn.2009.0169,
AUTHOR = {Marina Ziche, Lucia Morbidelli},
TITLE = {Molecular regulation of tumour angiogenesis by nitric oxide},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {4},
PAGES = {164--170},
URL = {http://www.techscience.com/ECN/v20n4/65885},
ISSN = {1952-4005},
ABSTRACT = {As tumors grow, their original vasculature can be insufficient to supply the growing tissue mass,
and consequently local hypoxia develops. Thus neovascularisation is a key feature determining growth and
metastasis of malignant tumors. This is, at least in part, mediated by humoral factors known to stimulate angio-genesis,
such as vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Among the
multiple angiogenic modulators released by tumor and stromal cells, a key role is played by nitric oxide (NO).
Beside its capacity to regulate permeability and blood flow, NO has been reported to exert angiogenic properties
in various tumor models. The focus of this review will be the proangiogenic role of NO in the tumor microenvi-ronment
and its multiple mechanism of action on vascular endothelium. Particular attention will be devoted
to the role of NO in regulating metalloproteinase activity on cultured microvascular endothelium and in the
in vivo rabbit cornea assay. Finally, the potential clinical outcomes and expectations related to this topic will be
discussed.},
DOI = {10.1684/ecn.2009.0169}
}