@Article{ecn.2009.0166,
AUTHOR = {Nikos E. Tsopanoglou, Michael E. Maragoudakis},
TITLE = {Thrombin’s central role in angiogenesis and pathophysiological processes},
JOURNAL = {European Cytokine Network},
VOLUME = {20},
YEAR = {2009},
NUMBER = {4},
PAGES = {171--179},
URL = {http://www.techscience.com/ECN/v20n4/65886},
ISSN = {1952-4005},
ABSTRACT = {A plethora of endogenous modulators of angiogenesis have been identified and their roles in the
molecular and cellular events that mediate and regulate angiogenesis have been proposed. In this review, we
summarize the recent findings on the role of thrombin/thrombosis on angiogenesis and other related pathophys-iological
processes. The mechanisms by which thrombin itself and its receptor PAR1 orchestrate many cellular
events through interaction with a variety of other factors and cell types are discussed. These new data point to
the complexity of the regulatory processes involved in the angiogenic cascade, which may be tissue specific, and
dependent upon the pathology involved. The understanding of these events may provide targets for therapeutic
intervention in disease states where angiogenesis is disturbed.},
DOI = {10.1684/ecn.2009.0166}
}