TY  - EJOU
AU  - Sato, Yasufumi 

TI  - Delta-like 4 and vasohibin 1: two endothelium-produced negative regulators of angiogenesis with distinctive roles
T2  - European Cytokine Network

PY  - 2009
VL  - 20
IS  - 4
SN  - 1952-4005

AB  - Angiogenesis is regulated by the local balance between angiogenesis stimulators and inhibitors.
A number of endogenous angiogenesis inhibitors have been found in the body. The origin of these inhibitors is
mostly extrinsic to the vasculature. Recently however, endothelial cells themselves have been found to produce
angiogenesis inhibitors including delta-like 4 and vasohibin 1. These intrinsic factors are thought to regulate
angiogenesis by an autoregulatory or negative-feedback mechanism. This review focuses on such negative regu-lators
of angiogenesis produced by endothelial cells.
KW  - angiogenesis
KW  -  endothelium
KW  -  autoregulation
KW  -  negative feedback

DO  - 10.1684/ecn.2009.0173