@Article{ecn.2010.0192,
AUTHOR = {Francesca Capone, Susan Costantini, Eliana Guerriero, Rosa Calemma, Maria Napolitano, Stefania Scala, Francesco Izzo, Giuseppe Castello},
TITLE = {Serum cytokine levels in patients with hepatocellular carcinoma},
JOURNAL = {European Cytokine Network},
VOLUME = {21},
YEAR = {2010},
NUMBER = {2},
PAGES = {99--104},
URL = {http://www.techscience.com/ECN/v21n2/65867},
ISSN = {1952-4005},
ABSTRACT = {The role played by the microenvironment in cancer induction, promotion and progression is
crucial. Emerging evidence suggests that cytokines, chemokines and growth factors are major players in carci-nogenesis.
Therefore, a detailed understanding of factors and mechanisms associated with the processes leading
from inflammation to cancer could improve the therapeutic strategies against this disease. We have used
hepatocarcinoma as our model in this study. We evaluated the serum levels of 50 different cytokines, chemo-kines
and growth factors in patients affected by HCC with chronic HCV-related hepatitis and liver cirrhosis
using multiplex biometric ELISA-based immunoassay. Our data showed that some pro-inflammatory molecules
were significantly up-regulated in these patients, and highlighted the complexity of the cytokine network in this
disease. This work suggests the need to monitor these proteins in order to define a profile that could charac-terize
patients with HCC or to help identify useful markers. This could lead to better definition of the disease
state, and to an increased understanding of the relationships between chronic inflammation and cancer.},
DOI = {10.1684/ecn.2010.0192}
}