TY  - EJOU
AU  - Arman, Ahmet 
AU  - Isık, Nihal 
AU  - Coker, Ajda 
AU  - Candan, Fatma 
AU  - Becit, Kezban Serap 
AU  - List, Edward O. 

TI  - Association between sporadic Parkinson disease and interleukin-1β -511 gene polymorphisms in the Turkish population
T2  - European Cytokine Network

PY  - 2010
VL  - 21
IS  - 2
SN  - 1952-4005

AB  - The pathogenesis of Parkinson Disease (PD) remains poorly understood; however, inflammation is
thought to play an important role in disease progression. Recent reports suggest that IL-1, a major proinflam-matory
cytokine, might play a role in PD progression. The purpose of this study was to determine the relation-ship
between IL-1 gene family polymorphisms [IL-1α (-889), IL-1Ra (VNTR) and IL-1β (-511, +3953)] and PD
in the Turkish population. In this study, we examined the genotypes of IL-1 gene family polymorphisms in
365 individuals, of which 199 were healthy control subjects and 166 were PD patients. No significant differences
were found in the genotype distribution or in the allele frequencies of IL-1α (-889), IL-1Ra (VNTR) and IL-1β
(+3953) between PD cases and control subjects. However, distribution of the IL-1β -511 2/2 (T/T) genotype was
found to be significantly lower in PD patients than in healthy controls (p = 0.018, x<sup>2</sup>
 : 8.242, OR: 2.211, 95% CI:
1.261-3.877). In addition, the IL-1β -511 allele 1 (C) frequency was significantly elevated in PD patients versus
controls (p = 0.048, x<sup>2</sup>
: 3.87, OR: 1.178, 95% CI: 0.999-1.388). These results suggest that IL-1α (-889), IL-1Ra
and IL-1β (+3953) gene polymorphisms have no association with PD, while allele 1 (C) of IL-1β (-511) is associ-ated
with PD and may provide a susceptibility factor for this disease in the Turkish population. Furthermore,
the 2/2 (T/T) genotype of IL-1β (-511) may protect individuals from PD.
KW  - interleukin-1
KW  -  cytokine
KW  -  polymorphism
KW  -  Parkinson disease

DO  - 10.1684/ecn.2010.0186