@Article{ecn.2010.0189,
AUTHOR = {Bartosz Hudzik, Janusz Szkodzinski, Aleksander Danikiewicz, Wojciech Romanowski, Andrzej Lekston, Lech Polonski, Barbara Zubelewicz-Szkodzinska},
TITLE = {Serum interleukin-6 concentration predicts contrast-induced nephropathy in patients undergoing percutaneous coronary intervention},
JOURNAL = {European Cytokine Network},
VOLUME = {21},
YEAR = {2010},
NUMBER = {2},
PAGES = {129--135},
URL = {http://www.techscience.com/ECN/v21n2/65871},
ISSN = {1952-4005},
ABSTRACT = {Background. Contrast media are being widely applied for both diagnostic and therapeutic
purposes. This has resulted in increasing incidence of contrast-induced nephropathy (CIN). Methods. We aimed
to investigate the value of baseline serum IL-6 concentrations in predicting CIN before the rise of serum
creatinine (SCr) in patients undergoing percutaneous coronary intervention. Seventy four Caucasian patients
were enrolled. CIN was defined as an increase in SCr concentration of more than 44 μmol/L, or a 25% increase
above baseline within 48 hours after contrast administration. Results. CIN developed in 16 out of 74 patients
(21.6%). The median concentration of IL-6 was 3.2 pg/mL. The median IL-6 concentration on admission was
lower in patients who subsequently did not develop CIN (2.7 pg/mL versus 8.3 pg/mL, p < 0.0001). Receiver
operating characteristics analysis showed a high diagnostic value of baseline SCr and IL-6. The cut-off value to
predict CIN for IL-6 was over 4.0 pg/mL (sensitivity 88%, specificity 76%, PPV 50%, NPV 96%). Multivariate
logistic regression analysis revealed three independent predictors of CIN: IL-6 (OR 1.43; 95%CI: 1.17-1.76),
serum creatinine (OR 1.79; 95%CI: 1.1-3.39), and ejection fraction (OR 0.86; 95%CI: 0.50-0.95). Conclusions.
Increased concentrations of IL-6 on admission are associated with subsequent CIN. Our study proposes that
IL-6 be added to the list of potential markers that could be used, along with renal function parameters, in
clinical practice.},
DOI = {10.1684/ecn.2010.0189}
}