TY  - EJOU
AU  - Mueller, Yvonne M. 
AU  - Katsikis, Peter D. 

TI  - IL-15 in HIV infection: pathogenic or therapeutic potential?
T2  - European Cytokine Network

PY  - 2010
VL  - 21
IS  - 3
SN  - 1952-4005

AB  - Recent studies have shown that interleukin-15 (IL-15) is produced during acute HIV and SIVinfection, and may impact viremia and viral set point. This is further supported by the findings that administra-tion of IL-15 during acute SIV infection dramatically increases viral set point. Although the role of intrinsicIL-15 during chronic infection is much less defined, in vivo administration of IL-15 does not increase viral repli-cation in SIV-infected animals. Recent data also suggest that IL-15 acts, not only on CD8+ T cells and naturalkiller cells, but also on effector memory CD4+ T cells. IL-15 clearly expands very different CD4+ T cell subpo-pulations than IL-2 in SIV-infected animals, and may be useful for the restoration of effector memory CD4+T cells that are depleted early in HIV and SIV infection. Understanding IL-15’s role in SIV infection may helpus to design novel therapeutic approaches to HIV infection.
KW  - IL-15
KW  -  HIV
KW  -  AIDS
KW  -  T cells

DO  - 10.1684/ecn.2010.0198