@Article{ecn.2010.0212,
AUTHOR = {Marine Desroches, Gauthier Louis, Aude Gleizes, Roman Krzysiek, Dominique Emilie},
TITLE = {Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients},
JOURNAL = {European Cytokine Network},
VOLUME = {21},
YEAR = {2010},
NUMBER = {4},
PAGES = {226--231},
URL = {http://www.techscience.com/ECN/v21n4/65839},
ISSN = {1952-4005},
ABSTRACT = {The use of TNF-α antagonists has substantially improved the care of many patients with inflam-matory and autoimmune diseases. However, approximately one third of such patients fail to respond well totreatment, regardless of the antagonist used or of the underlying disease. The mechanisms underlying these fail-ures are analyzed in this review, and proposals made concerning how best to adapt therapeutic decisions inthese instances.},
DOI = {10.1684/ecn.2010.0212}
}