TY  - EJOU
AU  - Desroches, Marine 
AU  - Louis, Gauthier 
AU  - Gleizes, Aude 
AU  - Krzysiek, Roman 
AU  - Emilie, Dominique 

TI  - Treatment failure with antagonists of TNF-α: mechanisms and implications for the care of patients
T2  - European Cytokine Network

PY  - 2010
VL  - 21
IS  - 4
SN  - 1952-4005

AB  - The use of TNF-α antagonists has substantially improved the care of many patients with inflam-matory and autoimmune diseases. However, approximately one third of such patients fail to respond well totreatment, regardless of the antagonist used or of the underlying disease. The mechanisms underlying these fail-ures are analyzed in this review, and proposals made concerning how best to adapt therapeutic decisions inthese instances.
KW  - TNF-α
KW  -  monoclonal antibodies
KW  -  biotherapies
KW  -  rheumatoid arthritis
KW  -  Crohn’s disease
KW  -  ankylosing spondylitis

DO  - 10.1684/ecn.2010.0212