@Article{ecn.2011.0274,
AUTHOR = {Rob J. W. Arts, Leo A. B. Joosten, Charles A. Dinarello, Bart Jan Kullberg, Jos W. M. van der Meer, Mihai G. Netea},
TITLE = {TREM-1 interaction with the LPS/TLR4 receptor complex},
JOURNAL = {European Cytokine Network},
VOLUME = {22},
YEAR = {2011},
NUMBER = {1},
PAGES = {11--14},
URL = {http://www.techscience.com/ECN/v22n1/65830},
ISSN = {1952-4005},
ABSTRACT = {Triggering receptor expressed on myeloid cells 1 (TREM-1) is an activating receptor expressed on
neutrophils and monocytes that amplifies inflammation induced by stimulation of pattern-recognition receptors. In
this study, several lines of evidence are presented that TREM-1 interacts with the toll-like receptor 4 (TLR4) receptor
complex, or is a component of this complex. Blocking anti-TREM-1 antibodies specifically inhibited LPS-induced
TNF-α production, while the alternative approach of blocking TLR4 by a specific inhibitor led to a down-regulation
of the effects of TREM-1 cross-linking. These data are in line with the TLR4-TREM1 co-localization in human
neutrophils and suggests that, at least some of the biological effects of TREM-1 may be due to its interaction with
the TLR4/LPS-receptor complex.},
DOI = {10.1684/ecn.2011.0274}
}