@Article{ecn.2011.0279,
AUTHOR = {Ferhat Cekmez, Yasemin Cekmez, Özgür Pirgon, Fuat Emre Canpolat, Secil Aydinöz, Osman Metin Ipcioglu, Ferhan Karademir},
TITLE = {Evaluation of new adipocytokines and insulin resistance in adolescents with polycystic ovary syndrome},
JOURNAL = {European Cytokine Network},
VOLUME = {22},
YEAR = {2011},
NUMBER = {1},
PAGES = {32--37},
URL = {http://www.techscience.com/ECN/v22n1/65833},
ISSN = {1952-4005},
ABSTRACT = {Aim. The aim of this study was to investigate the relationship between four circulating adipocytokines
(apelin, vaspin, visfatin, adiponectin) and markers of insulin sensitivity, in the context of polycystic ovary syndrome
(PCOS) in adolescents. Subjects and methods. 48, obese, adolescent girls (mean age: 15.6±3.4 years, mean body
mass index standard deviation score (BMI-SDS): 2.31±0.1), and 37 control subjects (mean age: 16.2±3 years,
mean BMI-SDS: 2.17±0.05) were enrolled the study. The diagnosis of PCOS was established according to the
Rotterdam criteria. Hyperinsulinism and insulin resistance was evaluated using the homeostasis model assessment
(HOMA-IR) from fasting samples. Plasma adiponectin and vaspin levels were determined by radioimmunoassay.
Determination of visfatin and apelin levels was performed by enzyme immunoassay. Results. HOMA-IR, apelin
and visfatin levels (4.9±2 versus 1.4±0.7, p<0.001; 2.2±1.1 versus 0.58±0.16, p<0.001; 31.3±11.1 versus 18.5±10.7,
p<0.001; respectively) were significantly elevated, and adiponectin levels (2.01±1.02 versus 12.5±6.2, p<0.001) were
significantly lower in the PCOS group. Vaspin levels were higher in the PCOS group than in the control group, but
the differences were not significant. Apelin and visfatin correlated positively and adiponectin correlated negatively
with BMI-SDS and HOMA-IR. Conclusion. Based on the findings of this study, apelin, visfatin and adiponectin
levels can be used as specific markers for insulin sensitivity, and these adipocytokines might play a part in the
pathogenesis of PCOS.},
DOI = {10.1684/ecn.2011.0279}
}