@Article{ecn.2011.0281,
AUTHOR = {Eduardo Tamayo, Ana Fernández, Raquel Almansa, Elena Carrasco, María Heredia, Carmen Lajo, Lisbeth Goncalves, Jose I. Gómez-Herreras, Raúl Ortiz de Lejarazu, Jesus F. Bermejo-Martin},
TITLE = {Pro- and anti-inflammatory responses are regulated simultaneously from the first moments of septic shock},
JOURNAL = {European Cytokine Network},
VOLUME = {22},
YEAR = {2011},
NUMBER = {2},
PAGES = {82--87},
URL = {http://www.techscience.com/ECN/v22n2/65821},
ISSN = {1952-4005},
ABSTRACT = {The relationships between cytokine responses in septic shock are currently poorly understood. Some
studies have pointed to a biphasic model, with an initial proinflammatory phase, followed by a reactive, antiinflammatory
response to explain the pathogenesis of the most severe form of sepsis. However, evidence for the
coexistence of both responses has been found. In this study, the plasma levels of 17 cytokines and chemokines, in 20
patients with septic shock, 11 patients with systemic inflammatory response syndrome (SIRS), during the first 24
hours following diagnosis, and 10 healthy controls, were analyzed and compared. Patients with septic shock showed
increased levels of IL-6, IL-8, MCP-1, MIP-1β, IFN-γ, GM-CSF and IL-10 compared to healthy controls. Patients
with SIRS showed higher levels of IL-6, IL-8, MCP-1, MIP-1β, G-CSF and IL-10 than controls. Patients with septic
shock showed higher levels of IL-8, GM-CSF, MIP-1β than those with SIRS. The Spearman test demonstrated a
positive association between the pro-inflammatory mediators IL-6, IL-8, MCP-1, MIP-1β, IFN-γ, GM-CSF and
the immunomodulatory cytokine IL-10 in septic shock. Consequently, correlation studies supported the notion
that secretion of pro- and anti-inflammatory mediators in septic shock occurs as a simultaneous immune response
program initiated early in the course of the disease, revealing that both types of cytokine play a role from the very
beginning of this life-threatening condition.},
DOI = {10.1684/ecn.2011.0281}
}