@Article{ecn.2011.0295,
AUTHOR = {Atefeh Golpaie, Narges Tajik, Farzad Masoudkabir, Zohreh Karbaschian, Mohammad Talebpour, Mostafa Hoseini, Mohammad Javad Hosseinzadeh-Attar},
TITLE = {Short-term effect of weight loss through restrictive bariatric surgery on serum levels of vaspin in morbidly obese subjects},
JOURNAL = {European Cytokine Network},
VOLUME = {22},
YEAR = {2011},
NUMBER = {4},
PAGES = {181--186},
URL = {http://www.techscience.com/ECN/v22n4/65816},
ISSN = {1952-4005},
ABSTRACT = {Background. The aims of this study were to evaluate the short-term effects of laparoscopic restrictive
bariatric surgery (LRBS) on plasma levels of vaspin and the potential associations of changes in vaspin levels with
changes in anthropometric indices, insulin-resistance and dietary intake. Methods. Thirty, severely obese subjects
(21 female; mean age, 32.5 years) with a mean body mass index (BMI) of 44.1 ± 4.9 kg/m<sup>2</sup> underwent LRBS.
Measurements of anthropometric indices, dietary intakes, physical activity and plasma vaspin concentrations were
performed prior to, and six weeks after LRBS. Insulin-sensitivity was estimated using the homeostasis model
assessment of insulin-resistance (HOMA-IR). Results. Six weeks after LRBS, BMI decreased to a mean of 38.4 ±
4.9 kg/m<sup>2</sup>. Significant reductions were also observed in waist circumference (WC), daily intakes of calorie, fat and
protein, and plasma concentrations of triglyceride. No significant change was observed in fasting levels of insulin,
blood sugar or HOMA-IR. Vaspin decreased significantly (0.26 ± 0.17 vs 0.36 ± 0.20, p=0.048) following surgery.
While the percentage change of vaspin was not correlated with percent changes in anthropometric indices and
HOMA-IR, it correlated positively with the percentage change in intake of calories, fat and protein: this correlation
remained significant even after adjustment for sex and changes in WC and HOMA-IR. Conclusion. Our study
suggests that LRBS decreases the serum vaspin concentrations in parallel with the restriction of dietary intake.
Furthermore, decreased levels of vaspin early after LRBS seem more likely to result from decreased dietary intake
rather than weight-loss-induced insulin sensitivity improvement.},
DOI = {10.1684/ecn.2011.0295}
}